GP6, glycoprotein VI platelet, 51206

N. diseases: 89; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3280120
Disease: Glycoprotein VI deficiency
Glycoprotein VI deficiency 		0.600 GermlineCausalMutation disease ORPHANET A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder. 19552682 2009
CUI: C3280120
Disease: Glycoprotein VI deficiency
Glycoprotein VI deficiency 		0.600 GermlineCausalMutation disease ORPHANET Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations. 19549989 2009
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.100 AlteredExpression disease BEFREE Platelet GPVI surface expression is enhanced following acute ischemic events like myocardial infarction and cerebral stroke, serves as an imminent diagnostic tool independent of markers of tissue necrosis, and is associated with poor prognosis. 27753514 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.100 AlteredExpression disease BEFREE Increased GPVI levels are associated with poor clinical outcome and are an early indicator for imminent myocardial infarction in patients with chest pain. 24553806 2014
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.050 AlteredExpression disease BEFREE Recent studies have shown that surface expression of GPVI on circulating platelets is enhanced in acute cardiovascular diseases such as myocardial infarction and ischaemic stroke. 24553806 2014
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.040 AlteredExpression disease BEFREE Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals. 27848272 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.040 AlteredExpression group BEFREE Platelet GPVI surface expression is enhanced following acute ischemic events like myocardial infarction and cerebral stroke, serves as an imminent diagnostic tool independent of markers of tissue necrosis, and is associated with poor prognosis. 27753514 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.040 AlteredExpression disease BEFREE Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals. 27848272 2017
CUI: C0011847
Disease: Diabetes
Diabetes 		0.030 AlteredExpression disease BEFREE Fc receptor expression correlated with GPVI expression and was found to be independently associated with diabetes (r = 0.529, P < 0.001). 15277394 2004
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.030 AlteredExpression group BEFREE Fc receptor expression correlated with GPVI expression and was found to be independently associated with diabetes (r = 0.529, P < 0.001). 15277394 2004
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.020 AlteredExpression disease BEFREE Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals. 27848272 2017
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.020 AlteredExpression disease BEFREE Soluble form of glycoprotein VI /platelet ratios on preoperative day and postoperative day 1 were significantly higher in LC-Sx than in non-LC-Sx. 29050501 2018
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.020 AlteredExpression disease BEFREE Increased soluble GPVI levels in cirrhosis: evidence for early in vivo platelet activation. 27416950 2017
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia 		0.020 AlteredExpression phenotype BEFREE Moreover, both human and murine GATA1-mutant platelets showed reduced adhesion and aggregate formation on a collagen matrix at an intermediate rate of shear, although this could not be accounted solely by the thrombocytopenia and altered GPVI expression, indicating that GATA1 regulates additional factors important for platelet activation under shear. 15701726 2005
CUI: C1264039
Disease: von Willebrand Disease, Type 1
von Willebrand Disease, Type 1 		0.020 AlteredExpression disease BEFREE Considering the recent suggestion that platelet membrane glycoprotein polymorphisms (PltGPs) may play a role as modulators of thromboembolic or haemorrhagic diseases, we investigated the role of different PltGPs and GPVI content in the clinical expression of patients with VWD type 1.The diagnosis of VWD (n = 76) was based on laboratory findings (VWF:Ag, VWF:RCo, VWF:CB, FVIII:C, and multimer analysis), family and personal history of bleeding. 14652648 2003
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia 		0.010 AlteredExpression phenotype BEFREE The expression level of this platelet collagen receptor may play a central role in the rapidly evolving coronary artery lesions that lead to malignant arrhythmia and sudden cardiac death. 10822074 2000
CUI: C0008031
Disease: Chest Pain
Chest Pain 		0.010 AlteredExpression phenotype BEFREE Increased GPVI levels are associated with poor clinical outcome and are an early indicator for imminent myocardial infarction in patients with chest pain. 24553806 2014
CUI: C0027022
Disease: Myeloproliferative disease
Myeloproliferative disease 		0.010 AlteredExpression group BEFREE GPVI and alpha 2 beta 1 levels were found to be significantly decreased on platelets from patients with myeloproliferative disorders (MPDs). 12829582 2003
CUI: C0040015
Disease: Thrombasthenia
Thrombasthenia 		0.010 AlteredExpression disease BEFREE We developed a panel of 14 platelet-specific metal-tagged antibodies (targeting cluster of differentiation [CD] 9, CD29, CD31, CD36, CD41, CD42a, CD42b, CD61, CD62P, CD63, CD107a, CD154, glycoprotein [GP] VI and activated integrin αIIbβ3) and compared this panel with two fluorescence flow cytometry (FFC) panels (CD41, CD42b, and CD61; or CD42b, CD62P, and activated integrin αIIbβ3) in the evaluation of activation-dependent changes in glycoprotein expression on healthy subject and Glanzmann thrombasthenia (GT) platelets. 29985398 2018
CUI: C0042974
Disease: von Willebrand Disease
von Willebrand Disease 		0.010 AlteredExpression disease BEFREE The levels of platelet GPVI were similar in symptomatic and asymptomatic VWD patients (109.6 +/- 58.4 vs 114.1 +/- 52.5, respectively; p: 0.77). 14652648 2003
CUI: C0221292
Disease: Basophilic leukemia
Basophilic leukemia 		0.010 AlteredExpression disease BEFREE To identify the thiol involved in disulfide bond formation, wild-type or mutant GPVI, where two available sulfhydryls (Cys-274 and Cys-338) were individually mutated to serine, was expressed in rat basophilic leukemia cells. 17690106 2007
CUI: C0340288
Disease: Stable angina
Stable angina 		0.010 AlteredExpression disease BEFREE Significantly elevated levels of sGPVI were observed in 10 patients with stable angina pectoris, with well-defined single vessel coronary artery disease and mean intracoronary shear estimates at 2935 seconds(-1) (peak shear, 19 224 seconds(-1)). 22431567 2012
CUI: C0409651
Disease: Seropositive rheumatoid arthritis
Seropositive rheumatoid arthritis 		0.010 AlteredExpression disease BEFREE We hypothesized that plasma levels of sGPVI would be increased among patients with seropositive RA as a consequence of antibody-induced platelet activation and GPVI shedding. 29141000 2017
CUI: C1292778
Disease: Chronic myeloproliferative disorder
Chronic myeloproliferative disorder 		0.010 AlteredExpression disease BEFREE In both the MPD and the control group, GPVI levels were found not to affect platelet function under high shear in whole blood. 12829582 2003
CUI: C1402315
Disease: Vascular lesions
Vascular lesions 		0.010 AlteredExpression disease BEFREE Non-invasive imaging studies with radiolabelled sGPVI-Fc show specific binding activity to vascular lesions in vivo. 24553806 2014